Improvement of liver injury induced by acetaminophen using black cherry (Prunus serotina Ehrh) powder and extract in rats

Authors

1 Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt.

2 Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt

Abstract

Liver injury is a major health problem .Continuous exposure to drugs, viral and bacterial infections and environmental toxins can trigger liver injury and eventually lead to various liver diseases.
The present investigation aims to elucidate the possible hepatotherapeutic effect of black cherry on liver injury induced by administration of acetaminophen (APAP) (which known as paracetamol) to adult male albino rats. Animals were divided into 5 groups, each of 6 rats. The first group was kept as normal control group received (basal diet only). The other four groups fed on basal diet and daily oral dose of paracetamol (400 mg/kg body weight) by gastric tube for one week to induce hepatotoxicity. The hepatotoxicity rats were classified into control (+ve) group and three treated rat groups which administered (selymarin 100 mg/kg/day), (10% dried black cherry) and (500mg/kg/day black cherry extract the treatment period was designed for 28days. Total antioxidant and total polyphenols and flavonoids were analyzed. Administration of APAP caused liver injury in rats evidenced by significant increase in serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatic malondialdehyde (MDA). In addition, significant decreases in hepatic catalase (CAT), glutathione (GSH). Treatment with silymarin, dried and extract of black cherry protect against liver injury as evidenced by significant decreases in MDA content, In addition, significant increases in hepatic CAT activity and GSH content. Conclusion: black cherry is rich source for polyphenols, flavonoids and antioxidant so it may be have protective and treatment role against liver toxicity in rats.

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