The present study was intended to investigate the potential ameliorative role of ashwagandha roots extract (ARE) on oxidative stress. Thirty (30) adult male albino rats were randomly distributed into 2 main groups. The first main group (6 rats) fed on the basal diet as a negative control group (normal rats). The second main group (24 rats) injected by a single intraperitoneal dose of potassium bromate at dose of 125 mg/kg body weight to induce oxidative stress then reclassified into 4 sub-groups one of them left as a positive control group and other three groups were given three doses of ashwagandha roots ethanolic extract (150, 300 and 450 mg/kg body weight) orally, respectively. The treatment lasted for 28 days. Also, the potential effect of ashwagandha roots extract against the human liver carcinoma cell line (HEPG2) has been studied in vitro. The obtained results revealed that oral administration of ashwagandha roots extract for 28days (150, 300,450 mg / kg body weight) caused significant (P ≤ 0.05) increases in HDL, Catalase and Glutathione transferase but with significant (P ≤ 0.05) decreases in serum glucose level, TC, TG, LDL, VLDL, MDA, kidney function and liver function markers. Alo, ashwagandha roots extract caused death of liver cancer cells. In conclusion, the study recommended using ashwagandha in our daily diets to block many complications by controlling
khateib, B. R. M., & Diab, L. A. E. A. E. (2021). The Potential Ameliorative Role of Ashwagandha (Withania somnifera) Roots Extract on Oxidative Stress. مجلة التربية النوعية و التکنولوجيا بحوث علمية و تطبيقية, 19(8), 22-36. doi: 10.21608/maat.2021.62489.1052
MLA
Basma ramadan mohammed khateib; Lamia Abd El-Hameed Abd El-Ghany Diab. "The Potential Ameliorative Role of Ashwagandha (Withania somnifera) Roots Extract on Oxidative Stress". مجلة التربية النوعية و التکنولوجيا بحوث علمية و تطبيقية, 19, 8, 2021, 22-36. doi: 10.21608/maat.2021.62489.1052
HARVARD
khateib, B. R. M., Diab, L. A. E. A. E. (2021). 'The Potential Ameliorative Role of Ashwagandha (Withania somnifera) Roots Extract on Oxidative Stress', مجلة التربية النوعية و التکنولوجيا بحوث علمية و تطبيقية, 19(8), pp. 22-36. doi: 10.21608/maat.2021.62489.1052
VANCOUVER
khateib, B. R. M., Diab, L. A. E. A. E. The Potential Ameliorative Role of Ashwagandha (Withania somnifera) Roots Extract on Oxidative Stress. مجلة التربية النوعية و التکنولوجيا بحوث علمية و تطبيقية, 2021; 19(8): 22-36. doi: 10.21608/maat.2021.62489.1052
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