Fenugreek as a promising treatment for infertility induced by obesity in female albino rats

Infertility in women is a health problem that may sometimes be due to obesity This study aimed to estimate the influence of Fenugreek in different concentrations obese induced infertile female albino rats. 28 and 7 white male albino rats were divided into 7 groups (5 rats for each group, 4 female and one male) weighing 220 ± 5g. The female rats in the first group fed on basal diet as a negative control; in the second group female rats were fed on a high-fat diet to induce obesity and were used as a positive control group. Female in 3, 4, 5, 6, and 7 groups fed on a high-fat diet with 1.5, 3.0, 4.5, 6.0, and 7.5 % of fenugreek powder. Bodyweight gain, feed intake, feed efficiency ratio was calculated, lipid, liver and kidney functions, were determined. Hormones (LH, FSH, and Estradiol) were measured. The effect of fenugreek on the fertility of obese induced female rats was estimated by determining the number of fertile females after mating and pregnancy and the number of offspring. The results revealed a significant performance of fenugreek as a treatment of infertility induced by obesity as well as improvement of the health. Group 7 where the highest (7.5%) of fenugreek were used recording the highest fertility, the highest LH, FSH, and estradiol levels. In addition, the best lipid profile, liver, and kidney functions were obtained. This study demonstrated that fenugreek seeds could be a promising approach to treating infertility disorders induced by obesity.