The effect of the caraway seeds aqueous extract on improving liver and kidney functions in autism induced by valproic acid in rats.

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Basic Education College the Public Authority for Applied Education and Training. Kuwait

Abstract

Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects how people interact with others, communicate, learn, and behave. The present study was designed to investigate the effect of the caraway seeds aqueous extract on improving liver and kidney functions in autism induced by valproic acid in rats. 35 pregnant females rats, 7 of them were used as control and the other 28 received a single oral dose of 800 mg/kg valproic acid VPA on the 12th day of gestation then their offspring after weaning were randomly distributed into equal groups (n=7) and treated for 25 days as group 1: (Cont-) offspring of control mothers, (Cont+) VPA injection served as control positive, group 3: VPA+ caraway (400/mg/kg b. wt, p.o), group 4: VPA+ RIS (1 mg/kg b. wt, p.o), and group 5: VPA+ caraway + RIS. The rats were sacrificed at the end of the experiment and serum was used for the estimation of serum aspartate transaminase (AST), alanine transaminase (ALT), uric acid, urea, and creatinine in addition to the histopathological study of the liver, brain and kidney. The results showed improvement in the weight, brain cells , liver, and kidney function by caraway with risperidone treatment in comparison with other treated groups. Conclusion: Consumption of aqueous extract of caraway seeds had a protective effect due to its effect on brain cells and liver and kidney functions in rats.The consuming caraway seeds has beneficial effects as a functional food in preventing oxidative damage caused by drugs or chemicals.

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